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This condition occurs approximately in about 5% of the population, however, among patients with cardiovascular diseases this condition occurs in up to 45% of patients and represents a serious risk of heart attack, endothelial dysfunction, arterial diseases, extracranial carotid artery disease, a common cause of the transient ischemic attack, termed also “mini-stroke”

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The 3-chloro-α-thiolactone was then proposed to undergo conversion to glyoxylate by hydrolysis and loss of Cl − and H 2 S (Finkelstein et al