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Both protein subunit and VLP vaccines thus mimic the principle of whole-virus vaccines but lack the genetic material required for replication, removing the risk of infection (141)
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In animal models, intra-articular administration of liraglutide reduced the secretion of inflammatory cytokines such as IL-6, the expression of inflammatory genes in chondrocytes, the amount of proinflammatory M1 macrophages, and improved pain-related behaviors 104
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