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Inhibitors of VEGF binding, like bevacizumab and B20.4-1-1 (in murine), have been shown to reduce vascularity in multiple disease models (Riggin et al., 2019)

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This type of ROS alters the mitochondrial DNA, resulting in deleterious changes in important proteins that form the enzyme complexes mentioned above, thereby generating the phenomenon known as mitochondrial dysfunction, which is responsible for increased synthesis of free radicals