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Microsomal Preparation Livers were thawed and homogenized in potassium phosphate buffer (pH 7.4) using a mortar and pestle on ice
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4.5 Metabolic dysregulation 4.5.1 Insulin signaling pathways in obesity and metabolic disease Metabolic tissues develop lipid intermediates alongside altered adipokine expression profiles and compromised mitochondrial function, progressively attenuating insulin responsiveness (64, 65)
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