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In support, we demonstrated that BPC 157 administration consistently decreased expression of Nfkb1 , as shown previously (Huang et al., 2015), which is considered a main activator of Nos2 , and both factors contribute to neuronal death (Liu et al., 2015)
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Under pathological conditions, the following three main mechanisms (oxidative stress, ER stress, and mitochondrial dysfunction) can affect drug metabolism of the liver, and drug metabolites further aggravate liver injury
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